Caveolin-1 as a potential new therapeutic target in multiple myeloma

Cancer Lett. 2006 Feb 20;233(1):10-5. doi: 10.1016/j.canlet.2005.02.035.


Caveolae are specialized flask-shaped lipid rafts enriched in cholesterol, sphingolipids, and structural marker proteins termed caveolins. Caveolins are highly conserved hairpin loop-shaped, oligomeric proteins of 22-24 kDa. Besides the plasma cell membrane, caveolins are also present in mitochondria, the endoplasmatic reticulum, the Golgi/trans-Golgi network, and secretory vesicles. They play a critical role in normal vesicular transport, cholesterol homeostasis, and signal transduction. Conversely, dysregulation of caveolin-1 has been associated with several human diseases including multiple myeloma, an incurable malignancy characterized by excess monoclonal plasma cells within the bone marrow. In this mini-review, we characterize the functional role of caveolin-1 in multiple myeloma, and present the preclinical rationale for novel potential therapeutic approaches targeting caveolin-1 in multiple myeloma.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Caveolae / chemistry
  • Caveolae / physiology
  • Caveolin 1 / antagonists & inhibitors*
  • Caveolin 1 / physiology
  • Cholesterol / biosynthesis
  • Drug Delivery Systems
  • Humans
  • Multiple Myeloma / drug therapy*
  • Multiple Myeloma / etiology
  • Phosphatidylinositol 3-Kinases / physiology
  • Vascular Endothelial Growth Factor A / physiology


  • Caveolin 1
  • Vascular Endothelial Growth Factor A
  • Cholesterol
  • Phosphatidylinositol 3-Kinases