B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization

Immunity. 2006 Feb;24(2):203-15. doi: 10.1016/j.immuni.2006.01.003.


Dendritic cell (DC) migration from the periphery to lymph nodes is regulated by the pattern of genes expressed by DCs themselves and by signals within the surrounding peripheral environment. Here, we report that DC mobilization can also be regulated by signals initiated within the downstream lymph nodes, particularly when lymph nodes enlarge as a consequence of immunization. Lymph node B lymphocytes orchestrate expansion of the lymphatic network within the immunized lymph node. This expanded network in turn supports increased DC migration from the periphery. These results reveal unique relationships between B cells, lymphatic vessels, and migratory DCs. Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigen Presentation
  • B-Lymphocytes / physiology*
  • Cell Adhesion Molecules
  • Cell Movement
  • Dendritic Cells / immunology*
  • Female
  • Freund's Adjuvant / pharmacology
  • Hemocyanins / pharmacology
  • Hypertrophy
  • Inflammation / immunology
  • Lymph Nodes / cytology
  • Lymph Nodes / immunology*
  • Lymph Nodes / metabolism*
  • Lymph Nodes / pathology
  • Lymphangiogenesis / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Nude
  • Mice, Transgenic
  • Skin / cytology
  • Skin / metabolism
  • Vaccination
  • Vascular Endothelial Growth Factor A / metabolism


  • Cell Adhesion Molecules
  • Vascular Endothelial Growth Factor A
  • Freund's Adjuvant
  • Hemocyanins