Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease

J Virol. 2006 Mar;80(5):2575-7. doi: 10.1128/JVI.80.5.2575-2577.2006.


Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded by the UL24 gene. The universal presence of UL24 in completed herpesviral genomes of three major subfamilies, Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, suggests a fundamental role for this predicted PD-(D/E)XK endonuclease activity in the viral life cycle.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alphaherpesvirinae / genetics
  • Amino Acid Sequence
  • Betaherpesvirinae / genetics
  • Computational Biology*
  • Endonucleases / genetics*
  • Endonucleases / metabolism
  • Gammaherpesvirinae / genetics
  • Herpesvirus 1, Human / genetics*
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Substrate Specificity
  • Viral Proteins / genetics*
  • Viral Proteins / metabolism*


  • UL24 protein, Human herpesvirus 1
  • Viral Proteins
  • Endonucleases