The main purpose of this study was to determine if increasing the volume of a resistance training program, while keeping the intensity the same would significantly increase the recovery energy expenditure, as measured by the excess post-exercise energy expenditure (EPEE). Fifteen resistance-trained women completed two resistance training protocols. Both protocols consisted of nine exercises performed to volitional fatigue, at the previously determined eight RM. The only difference between the two protocols was the number of sets (1-set or 3-sets). All subjects completed both protocols in a randomized and counterbalanced fashion. Energy expenditure, as determined by oxygen consumption and respiratory exchange ratio (RER), was measured continuously prior to exercise, during the exercise session, and during the entire 120 min of recovery. Fingertip blood lactate concentration was determined at baseline, immediately post-exercise, and every 30 min in recovery. The net energy expenditure during exercise was significantly greater during the 3-set protocol (661.9 +/- 43.9 kj) than the 1-set protocol (234.7 +/- 13.4 kj). However, per minute of exercise, there was no significant difference between the two protocols. During the 120 min of recovery, the net EPEE was not significantly different between the two protocols (93.3 +/- 20.1 kj following the 1-set protocol, and 94.1 +/- 7.1 kj following the 3-set protocol). However, when comparing the EPEE to the number of minutes spent in the exercise session, the 1-set protocol led to a significantly greater energy expenditure in the recovery period (1.0 +/- 0.22 kj/min) than did the 3-set protocol (0.4 +/- 0.03 kj/min). These data indicate that in previously trained women, increasing the volume of resistance training, from 1-set to 3-sets, while keeping the intensity the same will not significantly increase EPEE above what is found in a lower volume of work.