[Effect of unsaponifiable extracts of avocado and soybean (Piasclédine) on the collagenolytic action of cultures of human rheumatoid synoviocytes and rabbit articular chondrocytes treated with interleukin-1]

Rev Rhum Mal Osteoartic. 1991 Apr;58(4):241-5.
[Article in French]


In this work, the authors have studied the effect of advocate/soya-bean extracts (Piasclédine) on the collagenolytic activity of cultured rabbit articular chondrocytes and human rheumatoid synovial cells. Incubation of these cells for 48 h with 10 micrograms/ml of Piasclédine show that this drug slightly increases collagenase production. As expected, incubation of these cells with interleukin-1 (100 pg/ml) induces an important release of collagenase. Piasclédine partially reverses the effect of interleukin-1 on synovial cells and totally abolishes its action on chondrocytes. Moreover, incubation of the two cell types for 5 days with Piasclédine prior to a 48 h-exposure to interleukin-1 prevents partially the effect of interleukin-1. These data suggest a potential role for Piasclédine to limit the deleterious effects of interleukin-1 in osteoarticular diseases by reducing the capacity of this cytokine to stimulate collagenase production by synoviocytes and chondrocytes.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Cartilage, Articular / cytology
  • Cartilage, Articular / drug effects
  • Cartilage, Articular / enzymology*
  • Cells, Cultured
  • Collagen / metabolism*
  • Drug Combinations
  • Drug Evaluation
  • Humans
  • Interleukin-1 / pharmacology
  • Microbial Collagenase
  • Peptide Hydrolases / metabolism*
  • Phytosterols / pharmacology*
  • Phytosterols / therapeutic use
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rabbits
  • Rheumatic Diseases / drug therapy*
  • Synovial Membrane / drug effects
  • Synovial Membrane / enzymology*
  • Time Factors
  • Vitamin E / pharmacology*
  • Vitamin E / therapeutic use


  • Drug Combinations
  • Interleukin-1
  • Phytosterols
  • Plant Extracts
  • piascledine
  • Vitamin E
  • Collagen
  • Peptide Hydrolases
  • Microbial Collagenase