Autoimmune diagnostics in diabetes mellitus

Clin Chem Lab Med. 2006;44(2):133-7. doi: 10.1515/CCLM.2006.025.


Type 1 diabetes results from a specific destruction of the insulin-producing beta-cells of the pancreas. The disease is characterized by the appearance of specific autoantibodies against islet cell antigens. Autoantibodies to insulin, glutamic acid decarboxylase, tyrosine phosphatase IA-2 and cytoplasmic islet cell antibodies are useful markers for the differential diagnosis of type 1 diabetes when clinical and metabolic criteria alone do not allow definite classification. Autoimmune diagnostics is of particular importance in adults to discriminate between type 1 and type 2 diabetes and to assess the diagnosis of latent autoimmune diabetes in adults.

Publication types

  • Review

MeSH terms

  • Adult
  • Autoantibodies / blood
  • Child
  • Decision Support Techniques
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diagnosis, Differential
  • Humans
  • Islets of Langerhans / immunology
  • Risk


  • Autoantibodies