Primary progressive freezing gait: a syndrome with many causes

Neurology. 2006 Feb 14;66(3):411-4. doi: 10.1212/01.wnl.0000196469.52995.ab.

Abstract

Primary progressive freezing gait (PPFG) is characterized by early gait freezing and a stereotyped progression. Of nine patients followed up for 6 to 16 years, two were diagnosed pathologically: pallidonigroluysian degeneration (PNLD) and diffuse Lewy body disease. Four others evolved clinically into progressive supranuclear palsy and corticobasal degeneration. PPFG is not a distinct disorder but a syndrome with diverse causes. Long-term follow-up (> or =10 years) and postmortem are required for accurate diagnosis. PNLD may be the primary form of disease.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Amygdala / pathology
  • Basal Ganglia / pathology
  • Cerebral Cortex / pathology
  • Female
  • Gait*
  • Globus Pallidus / pathology
  • Humans
  • Lewy Body Disease / complications*
  • Lewy Body Disease / pathology
  • Male
  • Movement Disorders / etiology*
  • Movement Disorders / physiopathology*
  • Neurodegenerative Diseases / complications*
  • Neurodegenerative Diseases / pathology
  • Substantia Nigra
  • Supranuclear Palsy, Progressive / complications*
  • Supranuclear Palsy, Progressive / pathology