MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes

J Am Chem Soc. 2006 Feb 22;128(7):2172-3. doi: 10.1021/ja056354d.

Abstract

The very specific binding of the HgII ion unexpectedly and significantly stabilizes naturally occurring thymine-thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired sites, as well as novel double helical architectures consisting only of thymine-HgII-thymine pairs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Pairing
  • Cations, Divalent / chemistry
  • DNA / chemical synthesis
  • DNA / chemistry*
  • Mercury / chemistry*
  • Nuclear Magnetic Resonance, Biomolecular
  • Thymine / chemistry*

Substances

  • Cations, Divalent
  • DNA
  • Mercury
  • Thymine