Moving to the beat: a review of mammalian sperm motility regulation

Reprod Fertil Dev. 2006;18(1-2):25-38. doi: 10.1071/rd05120.


Because it is generally accepted that a high percentage of poorly motile or immotile sperm will adversely affect male fertility, analysis of sperm motility is a central part of the evaluation of male fertility. In spite of its importance to fertility, poor sperm motility remains only a description of a pathology whose underlying cause is typically poorly understood. The present review is designed to bring the clinician up to date with the most current understanding of the mechanisms that regulate sperm motility and to raise questions about how aberrations in these mechanisms could be the underlying causes of this pathology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium Signaling
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Humans
  • Male
  • Mammals / physiology*
  • Mitochondria / metabolism
  • Sperm Motility / physiology*
  • Spermatozoa / ultrastructure


  • Cyclic AMP-Dependent Protein Kinases