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Comparative Study
, 532 (3), 253-7

The Anorectic Effect of the Selective Dopamine D1-receptor Agonist A-77636 Determined by Meal Pattern Analysis in Free-Feeding Rats

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Comparative Study

The Anorectic Effect of the Selective Dopamine D1-receptor Agonist A-77636 Determined by Meal Pattern Analysis in Free-Feeding Rats

Steven J Cooper et al. Eur J Pharmacol.

Abstract

Free-feeding rats meet much of their daily energy requirements by consuming food in meals during the nocturnal phase of the night/day cycle. Meal pattern analysis methodology has been developed to record the patterns of meal taken over a 24-h period, and to provide detailed information on a number of meal-related parameters. Previous work indicates that selective dopamine D1-receptor agonists reduce food intake in short-term feeding tests under the control of homeostatic or hedonic factors. In the present study, our aim was to investigate the effects of the dopamine D1-receptor agonist, A-77636 (0.1-1.0 mg/kg, s.c.), administered just prior to the start of the night period, on the free-feeding and drinking patterns of rats maintained on a standard ad libitum diet. The results indicate that A-77636 exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration. We conclude that there is a dopamine D1-receptor involvement in the normal controls of meal size, and that selective D1-receptor agonists may act to limit meal size.

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