Endometrial adenocarcinoma presenting with an osseous metastasis

Gynecol Obstet Invest. 2006;61(4):200-2. doi: 10.1159/000091402. Epub 2006 Feb 8.


Background: Gynecologic cancers metastatic to bone are rare. Endometrial carcinoma usually presents with vaginal bleeding.

Case report: A 67-year-old woman presented with pain, erythema and swelling of the right foot and no history of postmenopausal bleeding. Biopsy revealed primary endometrioid carcinoma metastatic to the calcaneus, talus and metatarsal bones. Lower leg amputation, total abdominal hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node sampling were performed. Postoperatively the patient received cisplatin with adriamycin and megestrol acetate and is alive with no evidence of disease 20 months after the diagnosis.

Conclusion: Endometrial carcinoma can present as a metastatic lesion of bone.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / secondary*
  • Adenocarcinoma / therapy
  • Amputation, Surgical
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Neoplasms / secondary*
  • Bone Neoplasms / therapy
  • Cisplatin / therapeutic use
  • Combined Modality Therapy
  • Doxorubicin / therapeutic use
  • Endometrial Neoplasms / pathology*
  • Endometrial Neoplasms / therapy
  • Female
  • Humans
  • Hysterectomy
  • Megestrol Acetate / therapeutic use
  • Middle Aged


  • Doxorubicin
  • Cisplatin
  • Megestrol Acetate