Proteasome and transcription: a destroyer goes into construction

Bioessays. 2006 Mar;28(3):235-9. doi: 10.1002/bies.20379.


The proteasome is a proteolytic complex that is known to degrade proteins marked by the attachment of ubiquitin. Recently, it has become apparent that the proteasome has non-proteolytic roles. Several studies have implicated the proteasome in the regulation of transcription. A new study now shows that the proteasome facilitates the interaction of a histone acetyltransferase complex with transcriptional activators at active promoters.

MeSH terms

  • Histone Acetyltransferases / metabolism
  • Promoter Regions, Genetic
  • Proteasome Endopeptidase Complex / metabolism*
  • Protein Subunits / metabolism
  • Trans-Activators / metabolism
  • Transcription, Genetic*


  • Protein Subunits
  • Trans-Activators
  • Histone Acetyltransferases
  • Proteasome Endopeptidase Complex