Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes

Neurosci Lett. 2006 May 8;398(3):215-9. doi: 10.1016/j.neulet.2005.12.085. Epub 2006 Feb 9.


Genetic and pharmacological studies have suggested that brain-derived neurotrophic factor (BDNF) may be associated with the pathophysiology of bipolar disorder (BD). The present study investigated serum BDNF levels in manic, depressed, euthymic BD patients and in matched healthy controls, using an enzyme-linked immunosorbent assay (sandwich-ELISA). Serum BDNF levels were decreased in manic (p=0.019) and depressed (p=0.027) BD patients, as compared with euthymic patients and controls. Serum BDNF levels were negatively correlated with the severity of manic (r=-0.37, p=0.005) and depressive (r=-0.30, p=0.033) symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bipolar Disorder / metabolism*
  • Bipolar Disorder / physiopathology
  • Brain-Derived Neurotrophic Factor / blood*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Male
  • Reference Values
  • Severity of Illness Index


  • Brain-Derived Neurotrophic Factor