Activated c-Jun is present in neurofibrillary tangles in Alzheimer's disease brains

Neurosci Lett. 2006 May 8;398(3):246-50. doi: 10.1016/j.neulet.2006.01.031. Epub 2006 Feb 14.


Alzheimer's disease (AD) pathology is characterized by the presence of insoluble beta-amyoid deposits and neurofibrillary tangles containing hyperphosphorylated tau. Increased expression of the immediate early gene product c-Jun has also been reported in post-mortem AD brains, and the presence of upstream regulators of c-Jun has been described in tangle formations. Here, we report the presence of c-Jun specifically phosphorylated on ser-63, but not ser-73, in tangle-bearing neurons and in 'late-stage' extracellular tangles in AD brains. Western blot analysis confirmed the presence of c-Jun phosphorylated on ser-63 but not on ser-73 in AD brain tissue. The expression of differentially phosphorylated c-Jun in the AD brain may reflect the contradictory roles of these phosphorylation sites in neurons. Furthermore, the inappropriate sequestration of phosphorylated c-Jun in tangles in AD brains may contribute to AD pathology and neurodegeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / enzymology*
  • Brain / metabolism*
  • Enzyme Activation
  • Female
  • Humans
  • Immunohistochemistry
  • JNK Mitogen-Activated Protein Kinases / metabolism*
  • Male
  • Middle Aged
  • Neurofibrillary Tangles / enzymology*
  • Phosphorylation
  • Serine / metabolism


  • Serine
  • JNK Mitogen-Activated Protein Kinases