Regulation of bacterial virulence by two-component systems

Curr Opin Microbiol. 2006 Apr;9(2):143-52. doi: 10.1016/j.mib.2006.01.005. Epub 2006 Feb 14.


In bacteria, two-component systems (TCS) are widely used signal transduction devices which are engaged in a multitude of gene regulatory systems that respond to changing growth conditions. Many pathogenic bacteria encounter different microenvironments during their infectious cycle and their ability to efficiently adapt to different niches inside and outside of their host organisms is frequently mediated by TCSs, which can, therefore, be considered as an essential prerequisite for their pathogenicity. Although significant progress has been made in the elucidation of basic principles of the signal transduction process itself, in many pathogens the contribution of TCS to bacterial virulence is insufficiently recognized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological
  • Bacteria / genetics
  • Bacteria / pathogenicity*
  • Bacterial Physiological Phenomena*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Bordetella pertussis / pathogenicity
  • Bordetella pertussis / physiology
  • Gene Expression Regulation, Bacterial
  • Phosphorylation
  • Salmonella enterica / pathogenicity
  • Salmonella enterica / physiology
  • Signal Transduction / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Virulence


  • Bacterial Proteins
  • BvgA protein, Bacteria
  • Transcription Factors
  • bvgS protein, Bordetella pertussis