Comparison of Gd(DTPA-BMA) (Omniscan) Versus Gd(HP-DO3A) (ProHance) Relative to Gadolinium Retention in Human Bone Tissue by Inductively Coupled Plasma Mass Spectroscopy

Invest Radiol. 2006 Mar;41(3):272-8. doi: 10.1097/01.rli.0000186569.32408.95.

Abstract

Objective: The objective of this study was to determine the gadolinium (Gd) concentration remaining in human bone tissue after administration of standard clinical doses of 2 Gd-based contrast agents: ProHance and Omniscan.

Materials and methods: After administration of 0.1 mmol/kg of Gd chelate to patients undergoing hip replacement surgery, bone specimens were collected and analyzed, and compared with an age-matched control population without a history of Gd chelate administration. Bone specimens were collected fresh, refrigerated, and subsequently frozen. After grinding and freeze-drying, tissue digestion was performed using Teflon bombs and concentrated nitric acid. A method for analysis of Gd in bone specimens was developed and validated using inductively coupled plasma mass spectroscopy (ICP-MS).

Results: Results were compared with a previous study using a different technique for analysis of the same tissue specimens. Tissue retention was 1.77+/-0.704 microg Gd/g bone (n=9) for Omniscan and 0.477+/-0.271 microg Gd/g bone (n=10) for ProHance measured by ICP-MS. These findings confirmed results from the previous ICP-AES study.

Conclusion: Omniscan (Gd[DTPA-BMA]) left approximately 4 times (previous study 2.5 times) more Gd behind in bone than did ProHance (Gd[HP-DO3A]).

Publication types

  • Comparative Study

MeSH terms

  • Arthroplasty, Replacement, Hip
  • Connective Tissue
  • Contrast Media / metabolism
  • Contrast Media / pharmacokinetics*
  • Femur Head / metabolism*
  • Gadolinium
  • Gadolinium DTPA / metabolism
  • Gadolinium DTPA / pharmacokinetics*
  • Heterocyclic Compounds / metabolism
  • Heterocyclic Compounds / pharmacokinetics*
  • Humans
  • Mass Spectrometry*
  • Organometallic Compounds / metabolism
  • Organometallic Compounds / pharmacokinetics*
  • Regression Analysis

Substances

  • Contrast Media
  • Heterocyclic Compounds
  • Organometallic Compounds
  • gadoteridol
  • gadodiamide
  • Gadolinium
  • Gadolinium DTPA