Review
doi: 10.1038/nrm1861.
A visual approach to proteomics
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- PMID: 16482091
- DOI: 10.1038/nrm1861
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Review
A visual approach to proteomics
Nat Rev Mol Cell Biol.
2006 Mar.
Abstract
Cryo-electron tomography is an emerging imaging technique that has unique potential for molecular cell biology. At the present resolution of 4-5 nm, large supramolecular structures can be studied in unperturbed cellular environments and, in the future, it will become possible to map molecular landscapes inside cells in a more comprehensive manner. 'Visual proteomics' aims to complement and extend mass-spectrometry-based inventories, and to provide a quantitative description of the macromolecular interactions that underlie cellular functions.
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