Cell-signalling dynamics in time and space

Nat Rev Mol Cell Biol. 2006 Mar;7(3):165-76. doi: 10.1038/nrm1838.


The specificity of cellular responses to receptor stimulation is encoded by the spatial and temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to spatial gradients of signalling activities, which guide pivotal intracellular processes and tightly regulate signal propagation across a cell. Computational models provide insights into the complex relationships between the stimuli and the cellular responses, and reveal the mechanisms that are responsible for signal amplification, noise reduction and generation of discontinuous bistable dynamics or oscillations.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Physiological Phenomena*
  • Humans
  • Kinetics
  • Models, Biological
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Receptors, G-Protein-Coupled / physiology*
  • Signal Transduction / physiology*


  • Receptors, G-Protein-Coupled
  • Receptor Protein-Tyrosine Kinases