Clinical analysis of propofol deep sedation for 1,104 patients undergoing gastrointestinal endoscopic procedures: a three year prospective study

World J Gastroenterol. 2006 Jan 14;12(2):327-30. doi: 10.3748/wjg.v12.i2.327.


Aim: To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy.

Methods: In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus (0.5-1.5 mg/kg). Arterial blood pressure (BP) was monitored at 3 min intervals and heart rate and oxygen saturation (SpO2) were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure.

Results: A statistically significant reduction in mean arterial pressure was demonstrated (P < 0.001) when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60 mmHg, was noted in only 5 patients (0.5%). Oxygen saturation decreased from 96.5% to 94.4 % (P < 0.001). A critical decrease in oxygen saturation (< 90%) was documented in 27 patients (2.4%).

Conclusion: Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effects if carefully titrated. All the patients (and especially ASA III group) require monitoring and care of an anesthesiologist.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Pressure / drug effects
  • Conscious Sedation*
  • Endoscopy, Gastrointestinal*
  • Female
  • Heart Rate / drug effects
  • Humans
  • Hypnotics and Sedatives / pharmacology*
  • Male
  • Middle Aged
  • Oxygen / blood
  • Propofol / pharmacology*
  • Prospective Studies


  • Hypnotics and Sedatives
  • Oxygen
  • Propofol