The role of lipopolysaccharide-binding protein in modulating the innate immune response

Janine Zweigner; Ralf R Schumann; Joerg R Weber

doi:10.1016/j.micinf.2005.10.006

The role of lipopolysaccharide-binding protein in modulating the innate immune response

Microbes Infect. 2006 Mar;8(3):946-52. doi: 10.1016/j.micinf.2005.10.006. Epub 2006 Jan 13.

Authors

Janine Zweigner¹, Ralf R Schumann, Joerg R Weber

Affiliation

¹ Institut für Mikrobiologie und Hygiene, Charité-Universitaetsmedizin Berlin, Schumannstrasse 21/22, D-10117 Berlin, Germany.

PMID: 16483818
DOI: 10.1016/j.micinf.2005.10.006

Abstract

Lipopolysaccharide-binding protein (LBP) has a well-established role in Gram-negative infection. New data suggest a more expanded role for LBP as a general recognition molecule. Several bacterial surface components from Gram-positive pathogens are also recognized by this molecule. LBP may also serve as a clinical marker in severe infections and may carry therapeutic potential.

Publication types

Review

MeSH terms

Acute-Phase Proteins / immunology
Acute-Phase Proteins / metabolism*
Bacterial Infections / immunology
Carrier Proteins / immunology
Carrier Proteins / metabolism*
Humans
Immunity, Innate*
Lipopolysaccharides / immunology
Lipopolysaccharides / metabolism
Membrane Glycoproteins / immunology
Membrane Glycoproteins / metabolism*
Mycoses / immunology

Substances

Acute-Phase Proteins
Carrier Proteins
Lipopolysaccharides
Membrane Glycoproteins
lipopolysaccharide-binding protein