The consumption of lycopene and tomato-based food products is not associated with the risk of type 2 diabetes in women

J Nutr. 2006 Mar;136(3):620-5. doi: 10.1093/jn/136.3.620.


Lycopene is a major carotenoid with potent antioxidant properties that may provide protection against the development of type 2 diabetes mellitus (DM). In this study we examined the association between baseline dietary intakes of lycopene, lycopene-containing foods, and the subsequent development of type 2 DM in a large prospective cohort study. We analyzed a total of 35,783 women from the United States, aged > or =45 y and free from self-reported cardiovascular disease, cancer, and DM at baseline. Intakes of lycopene and total and individual tomato-based food products were assessed by a 131-item-validated semiquantitative food-frequency questionnaire. During a median follow-up of 10.2 y, 1544 cases of incident type 2 DM were documented. After adjusting for age, total energy intake, randomized treatment assignment, body mass index, and other known DM risk factors, the multivariate-adjusted relative risks and 95% CI of type 2 DM across increasing quintiles of dietary lycopene, were 1.00 (baseline), 1.10 (0.94-1.29), 1.10 (0.94-1.29), and 1.07 (0.91-1.26) (P linear trend = 0.56). Compared with women who consumed <1.5 servings/wk total tomato-based food products, women who consumed 1.5 to <4, 4 to <7, 7 to <10, and > or =10 servings/wk had multivariate relative risks (95% CI) of 1.03 (0.88-1.20), 1.02 (0.87-1.20), 1.09 (0.89-1.33), and 1.04 (0.80-1.36), respectively (P linear trend = 0.54). The associations for individual tomato-based food products were similar to the results for the combination of all tomato products. Our study found little evidence for an association between dietary intake of lycopene or lycopene-containing foods and the risk of type 2 DM.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology*
  • Boston / epidemiology
  • Carotenoids / administration & dosage
  • Carotenoids / pharmacology*
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Feeding Behavior*
  • Female
  • Humans
  • Lycopene
  • Middle Aged
  • Risk
  • Risk Factors
  • Solanum lycopersicum*


  • Antioxidants
  • Carotenoids
  • Lycopene