Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes

Cell Death Differ. 2006 Sep;13(9):1614-8. doi: 10.1038/sj.cdd.4401871. Epub 2006 Feb 17.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / pathology
  • Animals
  • Disease Susceptibility
  • Ectodermal Dysplasia / etiology*
  • Ectodermal Dysplasia / metabolism*
  • Ectodermal Dysplasia / pathology
  • Epithelium / metabolism
  • Epithelium / pathology
  • Hair / abnormalities
  • Hair / metabolism
  • Heterozygote
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Mice
  • Mice, Knockout
  • Neoplasms / etiology
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism*
  • Skin / metabolism
  • Skin / pathology
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Membrane Proteins
  • Perp protein, mouse
  • Phosphoproteins
  • Trans-Activators
  • Trp63 protein, mouse
  • Tumor Suppressor Protein p53