Exosomes biological significance: A concise review

Blood Cells Mol Dis. 2006 Mar-Apr;36(2):315-21. doi: 10.1016/j.bcmd.2005.12.001. Epub 2006 Feb 17.


Exosomes were initially thought to be a mechanism for removing unneeded membrane proteins from reticulocytes. Current studies have shown that the process of exosome formation extends to many mammalian cells. This concise review highlights the findings reported at a Workshop on Exosomes. Full knowledge of the contribution of exosomes to intercellular information transmission and the potential medical application of this knowledge will depend on the ingenuity of future investigators and their insight into biological processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endosomes / metabolism
  • Exocytosis
  • Membrane Proteins / metabolism*
  • Protein Transport
  • Reticulocytes / ultrastructure
  • Terminology as Topic
  • Transport Vesicles / physiology*


  • Membrane Proteins