Herpes gestationis (Pemphigoid gestationis)

Clin Dermatol. 2006 Mar-Apr;24(2):109-12. doi: 10.1016/j.clindermatol.2005.10.011.


Herpes gestationis, coined by Milton in 1872, or gestational pemphigoid is the most clearly characterized dermatosis of pregnancy. It is a rare vesiculo-bullous eruption that develops during the last trimester or even postpartum and creates severe pruritus. Its etiology is unknown, but it is considered as an autoimmune-mediated dermatosis closely related to the pemphigoid group. Herpes gestationis is associated with a positive C3 deposition along the base of the epidermis in salt-split skin, with increased frequency of HLA-DR3 and also the combination DR3 and DR4. It has a high risk of prematurity and disappears in the postpartum period within weeks or months.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Pemphigoid Gestationis / physiopathology*
  • Pregnancy