The When and Wheres of CDC25 Phosphatases

Curr Opin Cell Biol. 2006 Apr;18(2):185-91. doi: 10.1016/j.ceb.2006.02.003. Epub 2006 Feb 17.

Abstract

The CDC25 phosphatases are key regulators of normal cell division and the cell's response to DNA damage. Earlier studies suggested non-overlapping roles for each isoform during a specific cell cycle phase. However, recent data suggest that multiple CDC25 isoforms cooperate to regulate each cell cycle transition. For instance, although CDC25A was initially thought to exclusively regulate the G(1)-S transition, recent data demonstrate a significant role for CDC25A in the G(2)-M transition. Further evidence demonstrates that in addition to the ATM/ATR-CHK pathway, a p38-MAPKAP pathway is also involved in controlling CDC25 activity during G(2)/M checkpoint activation. Together with the fact that CDC25 overexpression is reported in many cancers, these data highlight the significance of developing specific CDC25 inhibitors for cancer therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Benzoquinones / therapeutic use
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / metabolism
  • Cell Cycle Proteins / physiology
  • Humans
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / metabolism
  • Isoenzymes / physiology
  • Models, Biological
  • Naphthoquinones / therapeutic use
  • Neoplasms / drug therapy
  • Neoplasms / enzymology
  • Quinolones / therapeutic use
  • Quinones / therapeutic use
  • Thiazoles / therapeutic use
  • cdc25 Phosphatases / antagonists & inhibitors
  • cdc25 Phosphatases / metabolism
  • cdc25 Phosphatases / physiology*

Substances

  • 2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone
  • BN 82685
  • Benzoquinones
  • Cell Cycle Proteins
  • Isoenzymes
  • NSC 663284
  • Naphthoquinones
  • Quinolones
  • Quinones
  • Thiazoles
  • cdc25 Phosphatases