Human cytomegalovirus glycoprotein-receptor interactions

Transplant Proc. 1991 Jun;23(3 Suppl 3):60-3.


The HCMV envelope glycoprotein having a molecular weight of 86 kd, gH, has been shown to react with a 92 kd protein that can be extracted from HEL fibroblasts. This HCMV-gp86 membrane receptor appears to be present on the surface of both HCMV-permissive and HCMV-non-permissive cells, suggesting that there are factors in addition to viral attachment governing the intracellular replicative process. Another HCMV envelope glycoprotein (gp130/55; gB homologue) binds predominantly to a 31 kd protein with minor bands at 180, 96, and 90 kd. HCMV-gp86 does not bind to the principal gp130/55 receptor.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antibodies, Monoclonal
  • Cytomegalovirus / physiology*
  • Glycoproteins / immunology
  • Glycoproteins / metabolism*
  • Humans
  • Receptors, Virus / physiology*
  • Viral Envelope Proteins / immunology
  • Viral Envelope Proteins / metabolism*
  • Virus Replication


  • Antibodies, Monoclonal
  • Glycoproteins
  • Receptors, Virus
  • Viral Envelope Proteins