Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS

Neuron. 1991 Jul;7(1):45-57. doi: 10.1016/0896-6273(91)90073-9.


A number of pharmacologically and electrophysiologically distinct voltage-dependent Ca2+ channels have been identified in mammalian neurons. Two rat brain Ca2+ channel alpha 1 subunits (rbC-I and rbC-II) have been isolated by molecular cloning and shown to be highly related (95%) to the cardiac dihydropyridine-sensitive Ca2+ channel. The rbC-II protein is distinct from rbC-I in that it contains a 3 amino acid insert in the putative cytoplasmic loop between domains II and III and a 28 amino acid substitution corresponding to the third transmembrane segment (S3) of the fourth domain. We show that rbC-I and rbC-II transcripts are generated by alternative splicing and that they are differentially expressed in the rat CNS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / metabolism*
  • Calcium Channels / genetics*
  • Calcium Channels / metabolism
  • DNA, Recombinant*
  • Genes
  • Molecular Sequence Data
  • Oocytes / metabolism
  • RNA Splicing*
  • Rats
  • Transcription, Genetic
  • Xenopus


  • Calcium Channels
  • DNA, Recombinant

Associated data

  • GENBANK/M67515
  • GENBANK/M67516
  • GENBANK/S61932
  • GENBANK/S61935
  • GENBANK/S70258
  • GENBANK/S70261
  • GENBANK/S70262
  • GENBANK/X57453
  • GENBANK/X57454
  • GENBANK/X57455