Regulation of Par6 by extracellular signals

Curr Opin Cell Biol. 2006 Apr;18(2):206-12. doi: 10.1016/ Epub 2006 Feb 20.


The critical regulator of polarity, Par6, is a key member of a multi-component polarity complex that controls a variety of cellular processes such as asymmetric cell division, establishment of epithelial apico-basal polarity, and polarized cell migration. Recently, we have come to understand how regulation of the Par6 interactome by extracellular cues such as integrin and transforming growth factor beta signalling regulates cell motility and tight junction dissolution. These studies have begun to elucidate how signalling to the polarity complex might regulate pathological processes such as tumour cell invasion and metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / physiology
  • Cell Polarity / physiology
  • Epithelial Cells / metabolism
  • Epithelial Cells / physiology
  • Humans
  • Models, Biological
  • Proteins / metabolism
  • Proteins / physiology*
  • Signal Transduction / physiology*
  • Transforming Growth Factor beta / metabolism
  • Transforming Growth Factor beta / physiology


  • Proteins
  • Transforming Growth Factor beta