Effect of optic material and haptic design on anterior capsule opacification and capsulorrhexis contraction

Am J Ophthalmol. 2006 Mar;141(3):488-493. doi: 10.1016/j.ajo.2005.10.041.


Purpose: To examine the influence of optic material (silicone and hydrophobic acrylic) and haptic design (one-piece and three-piece open loop) of sharp optic edge intraocular lenses (IOL) on anterior capsule opacification (ACO) and capsulorrhexis contraction.

Design: Randomized, controlled, double-blind clinical trial with intraindividual comparison.

Methods: This study was performed at the Department of Ophthalmology, Medical University of Vienna, Austria, and comprised 210 eyes of 105 patients with bilateral age-related cataract. In group 1 (n = 53 patients), a three-piece acrylic IOL was compared with a three-piece silicone IOL. In group 2 (n = 52 patients), the three-piece acrylic IOL was compared with the one-piece acrylic IOL. One year after the operation, standardized digital slit-lamp images of ACO were taken; 1 week and 1 year after the operation, digital retroillumination images were taken to assess capsulorrhexis size. The intensity of ACO was graded objectively (score, 0% to 100%), and the capsulorrhexis area (square millimeters) was determined objectively.

Results: One year after surgery, the mean ACO score was 21% for the acrylic and 20% for the silicone IOL (P = .4) in group 1 and 18% for both the three-piece and one-piece acrylic IOLs (P = .87) in group 2. Concerning the amount of capsulorrhexis contraction, there was no significant difference between the IOL types that were evaluated in this study (after Bonferroni-Holm correction, P > .05).

Conclusion: In the hydrophobic sharp optic edge IOLs that were examined, neither the optic material nor the haptic design had an influence on the amount of ACO or capsulorrhexis contraction.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acrylic Resins
  • Aged
  • Biocompatible Materials
  • Capsulorhexis*
  • Cataract / etiology*
  • Cataract Extraction
  • Contracture / etiology*
  • Double-Blind Method
  • Fibrosis
  • Humans
  • Lens Capsule, Crystalline / pathology*
  • Lens Implantation, Intraocular
  • Lenses, Intraocular*
  • Postoperative Complications*
  • Prosthesis Design
  • Silicone Elastomers


  • Acrylic Resins
  • Biocompatible Materials
  • Silicone Elastomers