Hypertrophic osteodystrophy in the Weimaraner dog: lack of association between DQA1 alleles of the canine MHC and hypertrophic osteodystrophy

Vet J. 2006 Mar;171(2):308-13. doi: 10.1016/j.tvjl.2004.11.015.


Hypertrophic osteodystrophy (HOD) is a canine bone disease that affects mainly large breed dogs, including the Weimaraner, and studies have shown a link between recent vaccination with a modified live virus and the onset of HOD in this breed. In humans, it has been suggested that human leukocyte antigen (HLA) alleles can influence antibody response to vaccination. The aim of this study was to investigate whether there is an association between the development of HOD in Weimaraners and MHC alleles at the DLA-DQA1 locus in a group of 33 unrelated dogs. The DQA1 allele and genotype frequencies were determined by sequence-based typing. Although clinical signs developed within six weeks of vaccination in all 12 dogs for which information was available, no association was found between DQA1 alleles and HOD in this population of Weimaraner dogs. A role for other immune-response genes in the pathogenesis of HOD should not however be ruled out. Whereas recent vaccination may be a trigger for the disease, it was concluded that there is no specific vaccine that is most responsible for the expression of the disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Animals
  • Bone Diseases / genetics
  • Bone Diseases / immunology
  • Bone Diseases / veterinary*
  • DNA / chemistry
  • DNA / genetics
  • Dog Diseases / genetics*
  • Dog Diseases / immunology*
  • Dogs
  • Female
  • HLA-DQ Antigens / genetics*
  • HLA-DQ Antigens / immunology*
  • HLA-DQ alpha-Chains
  • Male
  • Polymerase Chain Reaction / veterinary
  • Retrospective Studies
  • Sequence Analysis, DNA
  • Vaccination / adverse effects
  • Vaccination / veterinary*


  • HLA-DQ Antigens
  • HLA-DQ alpha-Chains
  • HLA-DQA1 antigen
  • DNA