The efficacy of povidone-iodine products against periodontopathic bacteria

Dermatology. 2006;212 Suppl 1:109-11. doi: 10.1159/000089208.


A total of 8 strains of 6 bacterial species, Porphyromonas gingivalis ATCC33277 and TDC286, Actinobacillus actinomycetemcomitans ATCC29523 and JP2, Fusobacterium nucleatum No. 2, Tannerella forsythensis ATCC43937, Prevotella intermedia ATCC25611 and Streptococcus anginosus ATCC33397, were treated with povidone-iodine (PVP-I) gargle (PVP-I: 0.47 and 0.23% w/v) or chlorhexidine gluconate (CHG) gargle (CHG: 0.002% w/v) for 15, 30 or 60 s, after which they were inoculated into various media, cultured and counted for residual bacteria. At both concentrations, PVP-I gargle reduced the viable cell count of all 8 bacterial strains to below the measurable limit within 15 s. By contrast, there were more than 1,000 viable colonies 60 s following treatment with the CHG gargle. The results demonstrate that povidone-iodine gargle has rapid bactericidal activity against the causative bacteria of periodontal disease.

MeSH terms

  • Aggregatibacter actinomycetemcomitans / drug effects
  • Anti-Infective Agents, Local / pharmacology*
  • Fusobacterium nucleatum / drug effects
  • Gram-Negative Bacteria / drug effects*
  • Humans
  • Mouth / microbiology*
  • Porphyromonas gingivalis / drug effects
  • Povidone-Iodine / pharmacology*
  • Prevotella intermedia / drug effects
  • Streptococcus anginosus / drug effects*


  • Anti-Infective Agents, Local
  • Povidone-Iodine