Antimicrobial principle from Aframomum longifolius

Planta Med. 2006 Feb;72(2):132-5. doi: 10.1055/s-2005-873192.

Abstract

Antimicrobial activity-directed fractionation of the seeds of Aframomum longifolius (Zingiberaceae) afforded two new labdane-type diterpenoids, 15-hydroxy-15-methoxylabda-8(17), 12( E)-dien-16-al (aframolin A) ( 1) and 8beta(17)-epoxy-15,15-dimethoxylabd-12( E)-en-16-al (aframolin B) ( 2), together with the known diterpenes labda-8(17),12( E)-diene-15,16-dial ( 3) and aframodial ( 4). Their structures were determined by spectroscopic methods. Compound 4 showed significant antimicrobial activity against Cryptococcus neoformans, Staphylococcus aureus and methicillin-resistant S. aureus (MRS) while 1, 2 and 3 were found to be inactive.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology*
  • Candida albicans / drug effects
  • Cryptococcus neoformans / drug effects
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Methicillin Resistance
  • Naphthalenes / chemistry
  • Naphthalenes / pharmacology*
  • Plant Preparations / chemistry
  • Plant Preparations / pharmacology
  • Spiro Compounds / chemistry
  • Spiro Compounds / pharmacology*
  • Staphylococcus aureus / drug effects
  • Zingiberaceae / chemistry*

Substances

  • Anti-Infective Agents
  • Diterpenes
  • Naphthalenes
  • Plant Preparations
  • Spiro Compounds
  • 8,17-epoxylabd-12-ene-15,16-dial