The level of prepulse inhibition in healthy individuals may index cortical modulation of early information processing

Brain Res. 2006 Mar 17;1078(1):168-70. doi: 10.1016/j.brainres.2006.01.056. Epub 2006 Feb 21.


This study examined whether baseline PPI levels reflect individual efficiency in tasks associated with routine versus supervisory attentional systems (SAS). PPI and neuropsychological data were collected from 30 healthy male subjects. High PPI was associated with shorter movement times on the 5-choice Reaction Time and shorter Subsequent Thinking Times in the Stockings of Cambridge test. These data suggest that high-PPI status reflects greater efficiency in tasks that engage SAS.

Publication types

  • Comparative Study

MeSH terms

  • Acoustic Stimulation / methods
  • Adult
  • Attention / physiology
  • Cerebral Cortex / physiology*
  • Choice Behavior / physiology
  • Humans
  • Male
  • Mental Processes / physiology*
  • Neural Inhibition / physiology*
  • Reaction Time / physiology*
  • Reflex, Startle / physiology
  • Time Factors