Clinical and experimental findings in humans and animals with chemotherapy-induced peripheral neuropathy

Minerva Anestesiol. 2006 Mar;72(3):151-69.


Pain arises from numerous causes in cancer patients. Well known to cancer care providers, but perhaps less well so to others, is that the main causes of pain in cancer patients in fact arise due to cancer treatments more so than the disease itself. In this paper clinical and laboratory findings on the characteristics of chemotherapy-induced neuropathic pain are reviewed and a scheme for the underlying mechanisms is outlined.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / toxicity
  • Behavior, Animal / physiology
  • Humans
  • Pain Measurement
  • Peripheral Nervous System Diseases / chemically induced*
  • Peripheral Nervous System Diseases / drug therapy
  • Peripheral Nervous System Diseases / epidemiology
  • Peripheral Nervous System Diseases / pathology


  • Antineoplastic Agents