ILK, PINCH and parvin: the tIPP of integrin signalling

Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31. doi: 10.1038/nrm1789.

Abstract

The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse signalling pathways. All these proteins have synergistic functions at focal adhesions, but recent work has indicated that these proteins might also have separate roles within a cell. They function as regulators of gene transcription or cell-cell adhesion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actinin / metabolism*
  • Amino Acid Sequence
  • Animals
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Integrins / metabolism*
  • Mice
  • Molecular Sequence Data
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction*
  • Zinc Fingers*

Substances

  • DNA-Binding Proteins
  • Integrins
  • Actinin
  • integrin-linked kinase
  • Protein-Serine-Threonine Kinases