Critical Nodes in Signalling Pathways: Insights Into Insulin Action

Nat Rev Mol Cell Biol. 2006 Feb;7(2):85-96. doi: 10.1038/nrm1837.

Abstract

Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Insulin / physiology*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Proto-Oncogene Proteins c-akt / metabolism
  • Receptor, Insulin / physiology*
  • Signal Transduction*

Substances

  • Insulin
  • Phosphatidylinositol 3-Kinases
  • Receptor, Insulin
  • Proto-Oncogene Proteins c-akt