Complex networks orchestrate epithelial-mesenchymal transitions

Nat Rev Mol Cell Biol. 2006 Feb;7(2):131-42. doi: 10.1038/nrm1835.


Epithelial-mesenchymal transition is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Embryonic Development*
  • Epithelial Cells / cytology*
  • Gastrula / cytology
  • Heart Valves / embryology
  • Humans
  • Mesoderm / cytology*
  • Mice
  • Neoplasms / etiology*
  • Neoplasms / pathology
  • Signal Transduction