Distribution of GABAA receptor subunit mRNAs in rat lumbar spinal cord

Brain Res Mol Brain Res. 1991 May;10(2):179-83. doi: 10.1016/0169-328x(91)90109-b.

Abstract

The expression of various GABAA receptor subunit mRNAs (alpha 1, alpha 2, alpha 3, alpha 5, beta 1, beta 2, beta 3, gamma 2, delta) was studied in the adult rat lumbar spinal cord by in situ hybridization. Of these, only alpha 2, alpha 3, beta 3 and gamma 2 mRNAs are expressed at significant levels. The alpha 3, beta 3 and gamma 2 transcripts are present in many neurons throughout the Rexed laminae, whereas the alpha 2 mRNA is restricted to motor neurons and adjacent cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoradiography
  • Base Sequence
  • DNA Probes
  • Macromolecular Substances
  • Molecular Sequence Data
  • Motor Neurons / physiology
  • Neurons / physiology
  • Oligonucleotide Probes
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics*
  • Rats
  • Receptors, GABA-A / genetics*
  • Spinal Cord / anatomy & histology
  • Spinal Cord / cytology
  • Spinal Cord / physiology*
  • Sulfur Radioisotopes

Substances

  • DNA Probes
  • Macromolecular Substances
  • Oligonucleotide Probes
  • RNA, Messenger
  • Receptors, GABA-A
  • Sulfur Radioisotopes