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, 12 (1), 9-14

Influenza Pandemics of the 20th Century

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Influenza Pandemics of the 20th Century

Edwin D Kilbourne. Emerg Infect Dis.

Abstract

Three worldwide (pandemic) outbreaks of influenza occurred in the 20th century: in 1918, 1957, and 1968. The latter 2 were in the era of modern virology and most thoroughly characterized. All 3 have been informally identified by their presumed sites of origin as Spanish, Asian, and Hong Kong influenza, respectively. They are now known to represent 3 different antigenic subtypes of influenza A virus: H1N1, H2N2, and H3N2, respectively. Not classified as true pandemics are 3 notable epidemics: a pseudopandemic in 1947 with low death rates, an epidemic in 1977 that was a pandemic in children, and an abortive epidemic of swine influenza in 1976 that was feared to have pandemic potential. Major influenza epidemics show no predictable periodicity or pattern, and all differ from one another. Evidence suggests that true pandemics with changes in hemagglutinin subtypes arise from genetic reassortment with animal influenza A viruses.

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References

    1. Taubenberger JK, Morens DM 1918 influenza: the mother of all pandemics. Emerg Infect Dis. 2006;12:15–22 - PMC - PubMed
    1. Shope RE The influenza viruses of swine and man. Harvey Lect. 1935–1936;30:183–213
    1. Chun JWH Influenza, including its infection among pigs. National Medical Journal of China. 1919;5:34–44
    1. Kilbourne ED The severity of influenza as a reciprocal of host susceptibility. In: Ciba Foundation Study Group, No. 4. Virus virulence and pathogenicity. Boston: Little, Brown and Co., 1960. p. 55–77.
    1. Smith W, Andrewes CH, Laidlaw PP A virus obtained from influenza patients. Lancet. 1933;2:66–8 10.1016/S0140-6736(00)78541-2 - DOI

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