MCM proteins and DNA replication

Curr Opin Cell Biol. 2006 Apr;18(2):130-6. doi: 10.1016/ Epub 2006 Feb 21.


The MCM proteins identify a group of ten conserved factors functioning in the replication of the genomes of archae and eukaryotic organisms. Among these, MCM2-7 proteins are related to each other and form a family of DNA helicases implicated at the initiation step of DNA synthesis. Recently this family expanded by the identification of two additional members that appear to be present only in multicellular organisms, MCM8 and MCM9. The function of MCM8 is distinct from that of MCM2-7 proteins, while the function of MCM9 is unknown. MCM1 and MCM10 are not related to this family, nor to each other, but also function in DNA synthesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / physiology*
  • DNA Replication*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Humans
  • Models, Genetic
  • Nuclear Proteins / genetics
  • Nuclear Proteins / physiology*
  • Phylogeny
  • Transcription Factors / genetics
  • Transcription Factors / physiology


  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Transcription Factors