Abstract
The synthesis of macrocyclic polyamine monometallic complexes containing imidazolium salt groups was reported. Their interaction with pUC19 plasmid DNA was studied. The result showed that these complexes can catalyze the DNA cleavage with unprecedented reactivity under physiological conditions.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Catalysis
-
Cyclams
-
DNA, Bacterial / chemistry*
-
DNA, Bacterial / drug effects
-
Heterocyclic Compounds / chemistry*
-
Imidazolines / chemistry*
-
Metals, Heavy / chemistry*
-
Molecular Structure
-
Organometallic Compounds* / chemical synthesis
-
Organometallic Compounds* / chemistry
-
Organometallic Compounds* / pharmacology
-
Plasmids / chemistry*
-
Structure-Activity Relationship
Substances
-
Cyclams
-
DNA, Bacterial
-
Heterocyclic Compounds
-
Imidazolines
-
Metals, Heavy
-
Organometallic Compounds
-
cyclen