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Case Reports
. 2006 Mar;35(2):200-1.
doi: 10.1093/ageing/afj042.

Metformin-related Vitamin B12 Deficiency

Case Reports

Metformin-related Vitamin B12 Deficiency

Kin Wah Liu et al. Age Ageing. .


Metformin is an invaluable hypoglycaemic agent. We report two cases who had symptomatic vitamin B12 deficiency related to metformin use; the mechanisms are discussed. The clinician must be aware of the possibility of metformin-associated B12 deficiency in users who suffer cognitive impairment, peripheral neuropathy, subacute combined degeneration of the cord or anaemia.

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