Tumours and tremors: how PTEN regulation underlies both

Br J Cancer. 2006 Mar 13;94(5):620-4. doi: 10.1038/sj.bjc.6602994.


Mutations of the tumour suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are seen in many human cancers. However, dysregulation of PTEN may be involved in other disease states such as Parkinson's disease. This minireview describes recent work examining PTEN regulation and its implications for the development of both cancer and neurodegenerative disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic
  • Drosophila melanogaster / genetics
  • Exons
  • Gene Expression Regulation
  • Humans
  • Mutation
  • Neoplasms / genetics*
  • Neoplasms / physiopathology*
  • PTEN Phosphohydrolase / genetics
  • PTEN Phosphohydrolase / physiology*
  • Parkinson Disease / genetics*
  • Parkinson Disease / physiopathology*
  • Signal Transduction


  • PTEN Phosphohydrolase
  • PTEN protein, human