Looking for inspiration: new perspectives on respiratory rhythm

Nat Rev Neurosci. 2006 Mar;7(3):232-42. doi: 10.1038/nrn1871.


Recent experiments in vivo and in vitro have advanced our understanding of the sites and mechanisms involved in mammalian respiratory rhythm generation. Here we evaluate and interpret the new evidence for two separate brainstem respiratory oscillators and for the essential role of emergent network properties in rhythm generation. Lesion studies suggest that respiratory cell death might explain morbidity and mortality associated with neurodegenerative disorders and ageing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Clocks / physiology*
  • Humans
  • Models, Biological
  • Respiration*
  • Respiratory Center / anatomy & histology
  • Respiratory Center / physiology
  • Respiratory Physiological Phenomena*
  • Respiratory System*