Structural systems biology: modelling protein interactions

Nat Rev Mol Cell Biol. 2006 Mar;7(3):188-97. doi: 10.1038/nrm1859.


Much of systems biology aims to predict the behaviour of biological systems on the basis of the set of molecules involved. Understanding the interactions between these molecules is therefore crucial to such efforts. Although many thousands of interactions are known, precise molecular details are available for only a tiny fraction of them. The difficulties that are involved in experimentally determining atomic structures for interacting proteins make predictive methods essential for progress. Structural details can ultimately turn abstract system representations into models that more accurately reflect biological reality.

Publication types

  • Review

MeSH terms

  • Cell Physiological Phenomena
  • Models, Biological
  • Models, Molecular
  • Molecular Biology / methods
  • Protein Conformation
  • Proteins / chemistry
  • Proteins / genetics*
  • Proteins / metabolism*


  • Proteins