No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults

J Psychiatr Res. 2007 Aug;41(5):404-9. doi: 10.1016/j.jpsychires.2006.01.004. Epub 2006 Feb 23.


Recent research has suggested that brain-derived neurotrophic factor (BDNF) may be implicated in the aetiology of mood-related phenotypes. Here we report an investigation of the association between a BDNF coding variant (Val66Met, rs6265) and mood status in a large non-clinical sample of men and women. We genotyped 7389 adult men and women, aged 41-80 years, selected from participants in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk, United Kingdom). Evidence of past year prevalent, lifetime and recurrent episodic major depressive disorder (MDD) and of past year prevalent and lifetime generalised anxiety disorder (GAD), defined by DSM-IV diagnostic criteria, was assessed through questionnaire together with a five-item version of the Mental Health Inventory (MHI-5). A total of 1214 (16.4%) participants reported lifetime MDD and 355 (4.8%) reported lifetime GAD. In this population based study we found no evidence to support an association between the BDNF gene Val66Met polymorphism and mood status.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brain-Derived Neurotrophic Factor / genetics*
  • DNA Primers / genetics
  • Diagnostic and Statistical Manual of Mental Disorders
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Mood Disorders / diagnosis
  • Mood Disorders / genetics*
  • Phenotype
  • Polymorphism, Genetic / genetics*
  • Prospective Studies


  • Brain-Derived Neurotrophic Factor
  • DNA Primers