Bacterial adhesion and entry into host cells

Cell. 2006 Feb 24;124(4):715-27. doi: 10.1016/j.cell.2006.02.012.


Successful establishment of infection by bacterial pathogens requires adhesion to host cells, colonization of tissues, and in certain cases, cellular invasion-followed by intracellular multiplication, dissemination to other tissues, or persistence. Bacteria use monomeric adhesins/invasins or highly sophisticated macromolecular machines such as type III secretion systems and retractile type IV pili to establish a complex host/pathogen molecular crosstalk that leads to subversion of cellular functions and establishment of disease.

Publication types

  • Review

MeSH terms

  • Bacteria / chemistry
  • Bacteria / genetics
  • Bacteria / pathogenicity*
  • Bacterial Adhesion*
  • Bacterial Outer Membrane Proteins / genetics*
  • Bacterial Outer Membrane Proteins / physiology
  • Epithelial Cells / microbiology
  • Fimbriae, Bacterial / genetics*
  • Fimbriae, Bacterial / physiology
  • Humans
  • Models, Biological
  • Virulence Factors / genetics


  • Bacterial Outer Membrane Proteins
  • Virulence Factors