Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 124 (4), 783-801

Pathogen Recognition and Innate Immunity

Affiliations
Review

Pathogen Recognition and Innate Immunity

Shizuo Akira et al. Cell.

Abstract

Microorganisms that invade a vertebrate host are initially recognized by the innate immune system through germline-encoded pattern-recognition receptors (PRRs). Several classes of PRRs, including Toll-like receptors and cytoplasmic receptors, recognize distinct microbial components and directly activate immune cells. Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of overlapping and unique genes involved in the inflammatory and immune responses. New insights into innate immunity are changing the way we think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.

Similar articles

  • Pathogen Recognition With Toll-like Receptors
    T Kawai et al. Curr Opin Immunol 17 (4), 338-44. PMID 15950447. - Review
    The innate immune system is an evolutionarily conserved system of defense against microbial infections. The family of Toll-like receptors is a major class of receptors th …
  • Toll-like Receptors: Critical Proteins Linking Innate and Acquired Immunity
    S Akira et al. Nat Immunol 2 (8), 675-80. PMID 11477402. - Review
    Recognition of pathogens is mediated by a set of germline-encoded receptors that are referred to as pattern-recognition receptors (PRRs). These receptors recognize conser …
  • Toll-like Receptors and Innate Immunity
    R Medzhitov. Nat Rev Immunol 1 (2), 135-45. PMID 11905821. - Review
    Toll-like receptors have a crucial role in the detection of microbial infection in mammals and insects. In mammals, these receptors have evolved to recognize conserved pr …
  • Innate Immune Recognition of Viral Infection
    T Kawai et al. Nat Immunol 7 (2), 131-7. PMID 16424890. - Review
    Induction of the antiviral innate immune response depends on recognition of viral components by host pattern-recognition receptors. Members of the Toll-like receptor fami …
  • Toll-like Receptor and RIG-I-like Receptor Signaling
    T Kawai et al. Ann N Y Acad Sci 1143, 1-20. PMID 19076341. - Review
    Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) constitute distinct families of pattern-recognition receptors that sense nucleic acids derived from viruses and …
See all similar articles

Cited by 3,037 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback