New roles for integrins in squamous-cell carcinoma

Nat Rev Cancer. 2006 Mar;6(3):175-83. doi: 10.1038/nrc1817.


Although integrins are known to mediate invasion and metastasis, recent studies reveal new ways in which they contribute to squamous-cell carcinoma. Integrin mutation or upregulation can expand the tumour stem-cell compartment by inhibiting differentiation or apoptosis. Integrins that are expressed by differentiated cells can stimulate or inhibit the proliferation of neighbouring tumour stem cells. These findings provide a mechanistic basis for the well-established links between altered integrin expression and tumour prognosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell / metabolism*
  • Carcinoma, Squamous Cell / pathology
  • Cell Differentiation
  • Cell Proliferation
  • Humans
  • Integrins / genetics
  • Integrins / metabolism*
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasms / immunology
  • Neoplasms / metabolism*
  • Neoplasms / pathology


  • Integrins