Lymphoid neogenesis in chronic inflammatory diseases

Nat Rev Immunol. 2006 Mar;6(3):205-17. doi: 10.1038/nri1786.


The frequent observation of organized lymphoid structures that resemble secondary lymphoid organs in tissues that are targeted by chronic inflammatory processes, such as autoimmunity and infection, has indicated that lymphoid neogenesis might have a role in maintaining immune responses against persistent antigens. In this Review, we discuss recent progress in several aspects of lymphoid neogenesis, focusing on the similarities with lymphoid tissue development, the mechanisms of induction, functional competence and pathophysiological significance. As more information on these issues becomes available, a better understanding of the role of lymphoid neogenesis in promoting chronic inflammation might eventually lead to new strategies to target immunopathological processes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemokine CCL21
  • Chemokines / physiology
  • Chemokines, CC / physiology
  • Chronic Disease
  • Germinal Center / physiology
  • Humans
  • Immunotherapy
  • Infections / immunology
  • Inflammation / immunology*
  • Inflammation / therapy
  • Lymphoid Tissue / physiology*


  • CCL21 protein, human
  • Chemokine CCL21
  • Chemokines
  • Chemokines, CC